Anti-bacterial Activity of Prenylated Xanthone from The Bark of Garcinia lowa
Abstract
Bioactivity-guided fractionation of a ethyl acetate extract of Garcinia lowa bark has led to the isolation and identification of a known prenylated xanthone, mangosharin, (2,6-dihydroxy-8-methoxy-5-(3-methylbut-2-enyl)-xanthone (1, 15.4 mg) The structure of the compound was identified from analysis of their spectroscopic data and by comparison with previous studies.Compound 1 showed anti-bacterial activity against Sreptococcus mutans with MIC value of 7.25 mg/mL.
Keywords
anti-bacterial; Garcinia lowa; mangosharin; prenylated xanthone
DOI: 10.15408/jkv.v2i2.4057
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Copyright (c) 2019 Darwati Darwati, Elisabeth Krismayanti, Supriyatna Supriyatna, Unang Supratman
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