Synthesis, Spectral, Anticancer Studies on Cu (II) Complex of 2,4,5-Triphenyl-1H-Imidazole

Fahimah Martak, Iin Candrawati, Ayu Widyasari


Schiff bases of 2,4,5-triphenyl-1H­-imidazole ligand and Cu(II) complex has been synthesized and characterized by 1H and 13C NMR, elemental analyses, molar conductance, thermal analysis (TGA), magnetic moment measurement, IR and UV-Vis. On the basis spectral studied and analytical data, it is evident that the Schiff base acts as monodentat ligand coordinating via nitrogen atom. The result showed that Cu(II) complex has octrahedral geometry. The studied complex was tested for anticancer activity. The anticancer activity of Cu(II) complex is evaluated against liver Carninoma (HEPG2)  cell lines. These compound exhibites a moderate and weak activity against HCT 116 cell line with IC50 19.8 mM.




Schiff bases; anticancer; imidazole; octahedral geometry


Joshi RS, Mandhane PG, Shaikh MU, Kale RP, Gill CH Chin. 2010. Potassium dihydrogen phosphate catalyzed one-pot synthesis of 2,4,5-triaryl-1H-imidazoles. Chem. Lett. 21: 429-432.

Mohammadi A, Keshvari H, Sandaroos R, Rouhi H, Sepehr ZJ. 2012. A novel polymeric catalyst for the one-pot synthesis of 2,4,5-triaryl-1H-imidazoles. Chem. Sci. 124: 717-722.

Rahmapreet Walia MD. Heditullah Syeda Farha Naaz, Khalid Iqbal, HS Lamda. 2011. Benzoimidazole derivatives-a review. International Journal of Research in Pharmacy and Chemistry. 2231-2781

Sadler PJ. 1991. Advance Inorganic Chemistry. first ed.

Shelke KF, Sapkal SB, Shitole NV, Shingate BB, Shingare MS Bull. 2009. Microwave-Assisted Synthesis of 3-Styrylchromones in Alkaline Ionic Liquid. Korean Chemical Soc. 30(12): 2883-2886.

Ucucu U, Karaburun NG, Isikdag I Farmaco. 2001. Ueber die einwirkung des ammoniaks auf glyoxal. European Journal of Organic Chemistry. 56: 285-290.

Wahyuningrum D. 2008. Sintesis Senyawa Turunan Imidazol dan Penentuan Aktivitas Inhibisi Korosinya pada Permukaan Baja Karbon. Thesis, Institut Teknologi Bandung.

Walia Vijay. 2011. The cancer center genetics branch, National Human Genome Research Institute, National Institutes of Health (NIH), Bethesda, Maryland: USA

Wang L, Woods KW, Li Q, Barr KJ, McCroskey RW, Hannick SM, Gherke L, Credo RB, Hui YH, Marsh K, Warner R, Lee JY, Zielinsky-Mozng N, Frost D, Rosenberg SH, Sham HL, J otent, 2002. Orally active heterocycle-based combretastatin A-4 analogues: synthesis, structure−activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation. Med. Chem. 45(8): 1697-1711.

Zala SP, Badmanaban R, Dhrubo JS, Chhaganbhai NP. 2012. Synthesis and biological evaluation of 2,4,5-triphenyl-1H-imidazole-1-yl Derivatives. Journal of Applied Pharmaceutical Science. 202-208.

Full Text: PDF

DOI: 10.15408/jkv.v2i2.3328


  • There are currently no refbacks.

Copyright (c) 2019 Fahimah Martak, Iin Candrawati, Ayu Widyasari

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.