Review: Potensi Resin Kemenyan (Styrax benzoin) dan Senyawa Aktifnya Dalam Pengobatan Penyakit
Abstract
Studies on drug discovery from natural ingredients are important to determine the pharmacological effects of the compound’s content so that it can be used to treat diseases. Kemenyan (Styrax benzoin) resin has been widely used by the local community for various purposes, including medicine. This review article aims to provide a comprehensive view of the potency of Kemenyan resin and its active compounds so that they could be used and developed to treat diseases in the future. The method used was based on searching for scientific literature in national and international journals. The results showed that the Kemenyan resin contains active compounds, including cinnamic acid, benzoic acid, benzaldehyde, benzyl benzoate, vanillin, styrene, styracin, coniferyl benzoate, benziresinol resin, resinotannol, sterols, phthalic acid, and sumaresorcinol. These compounds are known to have various pharmacological effects, including antibacterial, anesthetic, anti-inflammatory, antispasmodic, antimutagenic, fungicidal, herbicidal, tyrosinase inhibitory, and LDL synthesis inhibitory effects. Based on these studies, it can be concluded that the Kemenyan resin has great potential for the treatment of various diseases.
Keywords
References
Abd El‐Raouf, O.M., El‐Sayed, E.S.M. and Manie, M.F., 2015. Cinnamic acid and cinnamaldehyde ameliorate cisplatin‐induced splenotoxicity in rats. Journal of biochemical and molecular toxicology, 29(9), pp.426-431.
Apriyanti, M., 2018. Getah kemenyan sebagai bahan aditif pada campuran aspal Ac–Wc ditinjau dari sifat fisik bahan aspal dan nilai stabilitas marshall. Konstruksia, 9(1), pp.15-26.
Atia Sharif, H.N., Rehman, R., Mushtaq, A. and Rashid, U.A., 2016. Review on bioactive potential of Benzoin resin. Int. J. Chem. Biochem. Sci, 10, pp.106-110.
Burger, P., Casale, A., Kerdudo, A., Michel, T., Laville, R., Chagnaud, F. and Fernandez, X., 2016. New insights in the chemical composition of benzoin balsams. Food chemistry, 210, pp.613-622.
Dattner, A.M., 2003. From medical herbalism to phytotherapy in dermatology: back to the future. Dermatologic therapy, 16(2), pp.106-113.
Du, J., Singh, H. and Yi, T.H., 2016. Antibacterial, anti-biofilm and anticancer potentials of green synthesized silver nanoparticles using benzoin gum (Styrax benzoin) extract. Bioprocess and biosystems engineering, 39(12), pp.1923-1931.
Ernawati, T. and Budiana, A., 2016. Bioaktivitas Turunan Metil Sinamat Terhadap Pertumbuhan Bakteri Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Pseudomonas aureugenosa dan Jamur Candida albicans. Jurnal Kimia Valensi, 1(1), pp.60-64.
Gayatri, A., Rohaeti, E. and Batubara, I., 2019. Gum benzoin (Styrax benzoin) as antibacterial against Staphylococcus aureus. Al-Kimia, 7(2), pp.208-217.
Guo, J., Duan, J.A., Tang, Y. and Li, Y., 2011. Sedative and anticonvulsant activities of styrax after oral and intranasal administration in mice. Pharmaceutical biology, 49(10), pp.1034-1038.
Guo, S., Zhen, Y., Zhu, Z., Zhou, G. and Zheng, X., 2019. Cinnamic acid rescues behavioral deficits in a mouse model of traumatic brain injury by targeting miR-455-3p/HDAC2. Life sciences, 235, p.116819.
Harahap, M.I.M., 2019. Pengalaman Masyarakat Pakpak Bharat Merawat Luka Menggunakan Kemenyan. Jurnal Maternitas Kebidanan, 4(2), pp.62-72.
Hidayat, A., Iswanto, A.H., Susilowati, A. and Rachmat, H.H., 2018. Radical scavenging activity of kemenyan resin produced by an Indonesian native plant, Styrax sumatrana. Journal of the Korean Wood Science and Technology, 46(4), pp.346-354.
Hidayat, N., Yati, K., Krisanti, E.A. and Gozan, M., 2019, December. Extraction and antioxidant activity test of black Sumatran incense. In AIP Conference Proceedings (Vol. 2193, No. 1, p. 030017). AIP Publishing LLC.
Huang, L., Zhu, X., Zhou, S., Cheng, Z., Shi, K., Zhang, C. and Shao, H., 2021. Phthalic acid esters: Natural sources and biological activities. Toxins, 13(7), p.495.
Innocente, A., Casanova, B.B., Klein, F., Lana, A.D., Pereira, D., Muniz, M.N., Sonnet, P., Gosmann, G., Fuentefria, A.M. and Gnoatto, S.C., 2014. Synthesis of isosteric triterpenoid derivatives and antifungal activity. Chemical biology & drug design, 83(3), pp.344-349.
Jayusman. Mengenal Pohon Kemenyan (Styrax spp : Jenis Dengan Spektrum Pemanfaatan Luas yang Belum Dioptimalkan. 1st ed. IPB Press: Bogor, 2014.
Naghavi, M., Tamri, P. and Asl, S.S., 2021. Investigation of healing effects of cinnamic acid in a full-thickness wound model in rabbit. Jundishapur Journal of Natural Pharmaceutical Products, 16(1).
Nurwahyuni, I., Nababan, B., Pangoloi, S. and Situmorang, M., 2022. Cinnamic Acid in Frankincense Sap as a Criterion for Determining the Best Mother Plant for Vegetative Propagation of Styrax benzoin (Sumatra Benzoin) in Sumatra, Indonesia. International Journal of Forestry Research, 2022.
Purwanto, Y., Walujo, E.B. and Munawaroh, E., 2005. The ethnobotany of benzoin (Styrax spp.). Journal of Tropical Ethnobiology, 2(1), pp.18-34.
Rowe, R.C., Sheskey, P. and Quinn, M., 2009. Handbook of pharmaceutical excipients. Libros Digitales-Pharmaceutical Press.
Simatupang, D.P., Susanti, N. and Purba, J., 2021. Stability of Styrax benzoin extract and fraction with the addition of glycerol and tween 80. Jurnal Pendidikan Kimia, 13(2), pp.143-150.
Sohail Akhtar, M. and Alam, T., 2022. Chemistry, Biological Activities, and Uses of Benzoin Resin. In Gums, Resins and Latexes of Plant Origin: Chemistry, Biological Activities and Uses (pp. 1-22). Cham: Springer International Publishing.
Susanti, N., Purba, J. and Simatupang, D.P., 2021, March. Increased stability of styrax benzoin extract and fraction with the addition of cosolvents. In Journal of Physics: Conference Series (Vol. 1819, No. 1, p. 012049). IOP Publishing.
Wang, R., Yang, W., Fan, Y., Dehaen, W., Li, Y., Li, H., Wang, W., Zheng, Q. and Huai, Q., 2019. Design and synthesis of the novel oleanolic acid-cinnamic acid ester derivatives and glycyrrhetinic acid-cinnamic acid ester derivatives with cytotoxic properties. Bioorganic Chemistry, 88, p.102951.
Zafar, M.M.I., Hassan, F.O.U.Z.I.A., Naqvi, S.B.S., Muhammad, S., Hasan, F., Jabeen, S. and Israr, F., 2019. Evaluation of antibacterial activity of camphor, benzoin, cubebs, fenugreek, apricot and cinnamon leaf against standard cultures and clinical isolates of an array of organisms. Pak J Pharmacol, 36, pp.69-75.
DOI: 10.15408/pbsj.v5i1.30202
Refbacks
- There are currently no refbacks.
