Effect of Kelor Leaves (Moringa oleifera) in Liver Function of Streptozotocin induced Diabetic Sprague dawley Strain Male Rats

Nashih Abdillah, Devy Ariany, Muniroh . Muniroh


Background: Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia. Prolonged hyperglycemia can damage various organs of the body including the liver. Moringa oleifera leaves extract contain flavonoids which can decrease blood glucose levels and act as a hepatoprotector. To evaluate its hepatoprotective activity, liver function marker Serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvate transminase (SGPT ) was used. In this study, we aimed to determine the effect of Moringa oleifera leaves extract on the liver function test of male Sprague dawley rats that have DM due to streptozotocin induction.

Methods: This was experimental study conducted from February 2019 to July 2019 at Faculty of Medicine Laboratory, UIN Syarif Hidayatullah, Jakarta. This study conducted in 25 male Sprague dawley rats divided into 5 groups, those were negative controls group, positive controls group, and 3 treatment groups which given oral Moringa oleifera leaves extract at doses of 200 mg/kgBW, 400 mg/kgBW, and 600 mg/kgBW, respectively, for 14 days. Samples were collected on day 26th to measure SGOT and SGPT. Blood glucose levels were assayed on day 6th and 26th.

Results: There was no significant decrease in SGOT (p=0.069) and SGPT (p=0.345)  levels in the administration of Moringa oleifera leaves extract to male Sprague dawley rats with DM  induced by streptozotocin at a dose of 200 mg/KgBW and  400 mg/KgBW.

Conclusions: Moringa oleifera leaves extract did not significantly decrease SGOT and SGPT.


Moringa oleifera;SGOT;SGPT;Sprague dawley,;Streptozotocin

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Dyah P. Diagnosis dan Klasifikasi Diabetes Melitus dalam Buku Ajar Ilmu Penyakit Dalam Ed 6. Jakarta: Interna Publishing. 2014.

Jameson JL, et.al. Harrisons’s Principles of Internal Medicine. 20th Edition. New York: McGraw-Hill Education. 2018

Leite NC, Nogyeira, CA, Cardoso CR, Salles GF. Non-alcoholic fatty liver disesase and diabetes: from physiopathological interplay to diagnosis and treatment. World J Gastroenterol. 2014;20(26):8377-92.

Thesome G, ambachew S, fasil A, ambebe M. Prevalence of liver function test abnormality and associated factors in type 2 diabetes mellitus: a comparative cross-sectional study. EJIFCC. 2019 Oct;30(3): 303–16.

Rajanandh MG, Kavitha J. Quantitative Estimation of β-sitosterol, total phenolic, and flavonoid compound in the Leaves of Moringa oleifera. Int.J. PharmaTech Res. 2010;2(2):1409-14.

Omodanisi EI, Aboua GY, Chegou NN, Oguntibeju OO. Hepatoprotective, antihyperlipidemic, and anti-inflammatory activity of Moringa oleifera in diabetic induced damage in male Wistar rats. Pharmacognosy Res. 2017 Apr-Jun;9(2):182-7.

Yasa WP. Intake of Moringa oleifera leaf extract decrease Il-1 and TNF- levels in dislipidemic Wistar Rat model. Fakultas kedokteran Udayana. 2017.

Omodanisi EI, Aboua GY, Chegou NN, Oguntibeju OO. Therapeutic potentials and pharmacological properties of Moringa oleifera Lam in the treatment of diabetes mellitus and related complication. Tropical Journal of Pharmaceutical Research. 2017;16(7):1737-46.

Toppo R, et al. Hepatoprotective activity of Moringa oleifera against cadmium toxicity in rats. Vet World.2015;8(4):537-40.

Mostafavinia A, et.al. The Effect of dosage and the routes of administrations of streptozotocin and alloxan on induction rate of type 1 diabetes mellitus and mortality rate in rats. Lab Anlm Res.2016;32(3):160-5.

Lopez, AV, et. al. Effect of Moringa oleifera consumption on diabetic Rats. BMC Complementary and Alternative Medicine.2018;18(127):1-10.

Almatrafi MM, et.al. Moringa oleifera leaves prevent hepatic lipid accumulation and inflammation in guinea pigs by reducing the expression of genes involved in lipid metabolism. Int. J. Mol. 2017;18(1330):1-12.

Vergara-Jimenez M, Almatrafi M, Fernandez M. Bioactive components in Moringa oleifera leaves protect against chronic disease. Antioxidants.2017;6(4):1-13.

Sheikh A, et.al. Protective effects of Moringa oleifera lam. Leaves against arsenic–induced toxicity in mice. Asian Pac J Trop Biomed.2014;4(1):353-8.

DOI: https://doi.org/10.15408/avicenna.v3i2.27055 Abstract - 0 PDF - 0


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