Effect of 12 Weeks Vitamin D Supplementation (Alphacalcidol) on Blood Pressure in Elderly Women Patients

Achmad Zaki, Nida Nabila, M. Djauhari Widjajakusumah, Witri Ardini, Mery Nitalia

Abstract


Background : Cardiovascular disease have overtaken communicable disease for being the main killer worldwide. Hypertension or high blood pressure is one of the risk factors. Elderly women statistically have a high prevalence of hypertension. Vitamin D is known to affect blood pressure and many studies showed the association between vitamin D and blood pressure with varying result. This study aim to evaluate the effect of vitamin D supplementation (alphacalcidol) for 12 weeks and change in blood pressure of elderly women patients in community health service clinic (KPKM) Medical Faculty Syarif Hidayatullah State Islamic University of Jakarta (FK UIN Jakarta), with pre and hypertension grade 1 patients in majority. 

Methods :  Analytical pre-post study design was conducted as a part of an RCT (Randomized Controlled Trial) studies with 106 participants of elderly women (45 intervention group, 61 control group).

Results : Vitamin D deficiency in the intervention group significantly decreased post-supplementation from 22.2% to 8.9%. Subgroup analysis showed the decrease in blood pressure is greater in the subgroup middle-age elderly than young-age elderly category. Even though there was a significant change in the diastolic blood pressure in the subgroup of middle-age elderly post supplementation (p=0.03), Mann-Whitney statistical analysis showed that 12 weeks vitamin D supplementation (alphacalcidol) did not significantly effect the pre and post systolic nor diastolic blood pressure (p>0,05). 

Conclusion : The study did not found significant effect of 12 weeks Vitamin D (alphacalcidol) supplementation on blood pressure in elderly women patients.


Keywords


blood pressure, hypertension; vitamin D; alphacalcidol; elderly women

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References


World Health Organization (WHO). Hypertension [Internet]. [cited 2020 Sep 23]. Available from: https://www.who.int/health-topics/hypertension/

Jeong HY, Park KM, Lee MJ, Yang DH, Kim SH, Lee SY. Vitamin D and hypertension. Electrolyte Blood Press. 2017;15(1):1–11.

Kementrian Kesehatan RI. HASIL UTAMA RISKESDAS 2018 [Internet]. kemenkes.go.id. 2018. Accesed from: https://www.kemkes.go.id/resources/download/info-terkini/hasil-riskesdas-2018.pdf

Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, et al. Heart disease and stroke statistics-2013 update: A Report from the American Heart Association. Circulation. 2013;127.

Martins D, Wolf M, Pan D, Zadshir A, Tareen N, Thadhani R, et al. Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: Data from the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2007;167(11):1159–65.

Hermawan D, Kadarsih S, Sunarti, Astuti I, Agus ZAN. Efek asupan vitamin D terhadap tekanan darah sistolik tikus putih (Rattus norvegicus). J Gizi Klin Indones. 2012;9(1):10.

Gröber U, Kisters K. Influence of drugs on vitamin D and calcium metabolism. Dermatoendocrinol. 2012;4(2):158–66.

Vaidya A, Forman JP. Vitamin D and hypertension: Current evidence and future directions. Hypertension. 2010;56(5):774–9.

Boucher BJ. The problems of vitamin d insufficiency in older people. Aging Dis. 2012;3(4):313-329.

Maurya VK, Aggarwal M. Factors influencing the absorption of vitamin D in GIT: an overview. J Food Sci Technol. 2017;54(12):3753–65.

Lind L, Wengle B, Wide L, Sorensen OH, Ljunghall S. Hypertension in primary hyperparathyroidism—reduction of blood pressure by long-term treatment with vitamin d (Alphacalcidol) a double-blind, placebo-controlled study. Am J Hypertens. 1988;1(4):397–402.

Wei Zhen, Li Nanfang, Zhou Ling, et al. Effect of vitamin D3 supplement on blood pressure: a meta-analysis. Chin J Hypertension. 2017;25:636–642.

He S, Hao X. The effect of vitamin D3 on blood pressure in people with vitamin D deficiency: A system review and meta-analysis. Medicine (Baltimore). 2019;98(19):e15284.

Singh JN, Nguyen T, Dhamoon AS. Physiology, Blood Pressure Age Related Changes. StatPearls Publishing. 2019.

MacLaughlin J, Holick MF. Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest. 1985;76(4):1536–8.

Zhang D, Cheng C, Wang Y, Sun H, Yu S, Xue Y, dkk. Effect of Vitamin D on Blood Pressure and Hypertension in the General Population: An Update Meta-Analysis of Cohort Studies and Randomized Controlled Trials. Prev Chronic Dis. 2020 Jan 9;17:E03–E03.




DOI: https://doi.org/10.15408/avicenna.v2i2.23785 Abstract - 0 PDF - 0

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