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Cytotoxic Steroids From The Stembak of Chisocheton celebicus KOORD

Dewa Gede Katja, Desi Harneti, Tri Mayanti, Nurlelasari Nurlelasari, Rani Maharani, Yoshihito Shiono, Unang Supratman

Abstract


In the course of our continuing search for anticancer compounds from Chisocheton species, three steroids, stigmast-5-en-3β-ol (1), stigmast-5-en-3β-ol-3-O-β-D-glucopyranoside (2) and stigmast-5,22-dien-3β-ol-3-O-β-D-glucopyranoside (3), were obtained from the stembark of Chisocheton celebicus. The structures of compound 1-3 were identified with spectroscopic data including IR, 1D-NMR, 2D-NMR and TOF-MS, as well as by comparing with those spectral data previously. Compounds 1-3, were evaluated for their cytotoxic effects against P-388 murine leukemia cells and displayed the cytotoxicity activity with IC50 values of 12.45 ± 0.050, 52.27 ± 0.031 and 62.52 ± 0.076 µg/mL, respectively.


Keywords


Chisocheton celebicus koord; cytotoxic activity; Meliaceae; P-388 murine leukemia cells; steroid

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DOI: 10.15408/jkv.v5i2.12132

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